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Targeted degradation of the retinoblastoma protein by human papillomavirus E7-E6 fusion proteins.

The E6 and the E7 proteins of the oncogenic human papillomavirus types 16 and 18 can stably associate with p53 and the retinoblastoma protein, respectively. The E6-p53 interaction results in the accelerated degradation of p53 in vitro via the ubiquitin-dependent proteolysis system. In this study we...

詳細記述

保存先:
書誌詳細
出版年:EMBO J
主要な著者: Scheffner, M, Münger, K, Huibregtse, J M, Howley, P M
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 1992
主題:
オンライン・アクセス:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC556717/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1321031/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1992.tb05307.x
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