Pharmacokinetic and Pharmacodynamic Evaluation of Marbofloxacin and PK/PD Modeling against Escherichia coli in Pigs

The aim of this study was to evaluate the activity of marbofloxacin and establish the optimal dose regimens for decreasing the development of fluoroquinolone resistance in pigs against Escherichia coli with ex vivo pharmacokinetic/pharmacodynamic (PK/PD) modeling. The recommended dose (2 mg/kg body...

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發表在:Front Pharmacol
Main Authors: Lei, Zhixin, Liu, Qianying, Xiong, Jincheng, Yang, Bing, Yang, Shuaike, Zhu, Qianqian, Li, Kun, Zhang, Shishuo, Cao, Jiyue, He, Qigai
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2017
主題:
Pharmacology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5566571/
https://ncbi.nlm.nih.gov/pubmed/28871226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00542
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