Pharmacokinetic and Pharmacodynamic Evaluation of Marbofloxacin and PK/PD Modeling against Escherichia coli in Pigs

The aim of this study was to evaluate the activity of marbofloxacin and establish the optimal dose regimens for decreasing the development of fluoroquinolone resistance in pigs against Escherichia coli with ex vivo pharmacokinetic/pharmacodynamic (PK/PD) modeling. The recommended dose (2 mg/kg body...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Lei, Zhixin, Liu, Qianying, Xiong, Jincheng, Yang, Bing, Yang, Shuaike, Zhu, Qianqian, Li, Kun, Zhang, Shishuo, Cao, Jiyue, He, Qigai
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5566571/
https://ncbi.nlm.nih.gov/pubmed/28871226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00542
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