The resolution of acute inflammation induced by cyclic AMP is dependent on annexin A1

Annexin A1 (AnxA1) is a glucocorticoid-regulated protein known for its anti-inflammatory and pro-resolving effects. We have shown previously that the cAMP-enhancing compounds rolipram (ROL; a PDE4 inhibitor) and Bt(2)cAMP (a cAMP mimetic) drive caspase-dependent resolution of neutrophilic inflammati...

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Vydáno v:J Biol Chem
Hlavní autoři: Lima, Kátia M., Vago, Juliana P., Caux, Thaís R., Negreiros-Lima, Graziele Letícia, Sugimoto, Michelle A., Tavares, Luciana P., Arribada, Raquel G., Carmo, Aline Alves F., Galvão, Izabela, Costa, Bruno Rocha C., Soriani, Frederico M., Pinho, Vanessa, Solito, Egle, Perretti, Mauro, Teixeira, Mauro M., Sousa, Lirlândia P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5566529/
https://ncbi.nlm.nih.gov/pubmed/28655761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.800391
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