The resolution of acute inflammation induced by cyclic AMP is dependent on annexin A1

Annexin A1 (AnxA1) is a glucocorticoid-regulated protein known for its anti-inflammatory and pro-resolving effects. We have shown previously that the cAMP-enhancing compounds rolipram (ROL; a PDE4 inhibitor) and Bt(2)cAMP (a cAMP mimetic) drive caspase-dependent resolution of neutrophilic inflammati...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Lima, Kátia M., Vago, Juliana P., Caux, Thaís R., Negreiros-Lima, Graziele Letícia, Sugimoto, Michelle A., Tavares, Luciana P., Arribada, Raquel G., Carmo, Aline Alves F., Galvão, Izabela, Costa, Bruno Rocha C., Soriani, Frederico M., Pinho, Vanessa, Solito, Egle, Perretti, Mauro, Teixeira, Mauro M., Sousa, Lirlândia P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5566529/
https://ncbi.nlm.nih.gov/pubmed/28655761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.800391
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