Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type

Amyloid aggregates found in the brain of patients with neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are thought to spread to increasingly larger areas of the brain through a prion-like seeding mechanism. Not much is known about which cell surface receptors may be involv...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Ihse, Elisabet, Yamakado, Hodaka, van Wijk, Xander M., Lawrence, Roger, Esko, Jeffrey D., Masliah, Eliezer
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5566500/
https://ncbi.nlm.nih.gov/pubmed/28827536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08720-5
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