Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type

Amyloid aggregates found in the brain of patients with neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are thought to spread to increasingly larger areas of the brain through a prion-like seeding mechanism. Not much is known about which cell surface receptors may be involv...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Ihse, Elisabet, Yamakado, Hodaka, van Wijk, Xander M., Lawrence, Roger, Esko, Jeffrey D., Masliah, Eliezer
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5566500/
https://ncbi.nlm.nih.gov/pubmed/28827536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08720-5
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