Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR(+) endosome trafficking

T cell receptor (TCR) signaling is important for T cell homeostasis and function. However, how surface TCR levels are regulated and its biological significance on T cells remains largely unknown. Here, we show that the T cell-specific deletion of Arpc2, a component of Arp2/3 complex, results in comp...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Zhang, Ye, Shen, Hao, Liu, Haifeng, Feng, Haiyun, Liu, Yan, Zhu, Xiaoyan, Liu, Xiaolong
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5566485/
https://ncbi.nlm.nih.gov/pubmed/28827576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08357-4
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