pH-sensitive and folic acid-targeted MPEG-PHIS/FA-PEG-VE mixed micelles for the delivery of PTX-VE and their antitumor activity

The aim of this study was to simultaneously introduce pH sensitivity and folic acid (FA) targeting into a micelle system to achieve quick drug release and to enhance its accumulation in tumor cells. Paclitaxel-(+)-α-tocopherol (PTX-VE)-loaded mixed micelles (PHIS/FA/PM) fabricated by poly(ethylene g...

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Bibliografiske detaljer
Udgivet i:Int J Nanomedicine
Main Authors: Di, Yan, Li, Ting, Zhu, Zhihong, Chen, Fen, Jia, Lianqun, Liu, Wenbing, Gai, Xiumei, Wang, Yingying, Pan, Weisan, Yang, Xinggang
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2017
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5566413/
https://ncbi.nlm.nih.gov/pubmed/28860753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S141982
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