Improving aqueous solubility and antitumor effects by nanosized gambogic acid-mPEG(2000) micelles

The clinical application of gambogic acid, a natural component with promising antitumor activity, is limited due to its extremely poor aqueous solubility, short half-life in blood, and severe systemic toxicity. To solve these problems, an amphiphilic polymer-drug conjugate was prepared by attachment...

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Detalhes bibliográficos
Main Authors: Cai, Lulu, Qiu, Neng, Xiang, Mingli, Tong, Rongsheng, Yan, Junfeng, He, Lin, Shi, Jianyou, Chen, Tao, Wen, Jiaolin, Wang, Wenwen, Chen, Lijuan
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883552/
https://ncbi.nlm.nih.gov/pubmed/24403830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S54050
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