Alpha-1 Antitrypsin PiMZ Genotype Is Associated with Chronic Obstructive Pulmonary Disease in Two Racial Groups

Rationale: Alpha-1 antitrypsin deficiency, caused primarily by homozygosity for the Z allele of the SERPINA1 gene, is a well-established genetic cause of chronic obstructive pulmonary disease (COPD). Whether the heterozygous PiMZ genotype for alpha-1 antitrypsin confers increased risk for COPD has b...

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Bibliographic Details
Published in:Ann Am Thorac Soc
Main Authors: Foreman, Marilyn G., Wilson, Carla, DeMeo, Dawn L., Hersh, Craig P., Beaty, Terri H., Cho, Michael H., Ziniti, John, Curran-Everett, Douglas, Criner, Gerard, Hokanson, John E., Brantly, Mark, Rouhani, Farshid N., Sandhaus, Robert A., Crapo, James D.
Format: Artigo
Language:Inglês
Published: American Thoracic Society 2017
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5566271/
https://ncbi.nlm.nih.gov/pubmed/28380308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1513/AnnalsATS.201611-838OC
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