The gRNA-miRNA-gRNA Ternary Cassette Combining CRISPR/Cas9 with RNAi Approach Strongly Inhibits Hepatitis B Virus Replication

The CRISPR/Cas9 system is a novel genome editing technology which has been successfully used to inhibit HBV replication. Here, we described a novel gRNA-microRNA (miRNA)-gRNA ternary cassette driven by a single U6 promoter. With an anti-HBV pri-miR31 mimic integrated between two HBV-specific gRNAs,...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Wang, Jie, Chen, Ran, Zhang, Ruiyang, Ding, Shanlong, Zhang, Tianying, Yuan, Quan, Guan, Guiwen, Chen, Xiangmei, Zhang, Ting, Zhuang, Hui, Nunes, Frederick, Block, Timothy, Liu, Shuang, Duan, Zhongping, Xia, Ningshao, Xu, Zhongwei, Lu, Fengmin
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5566108/
https://ncbi.nlm.nih.gov/pubmed/28839466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.18114
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