Epigenetically induced ectopic expression of UNCX impairs the proliferation and differentiation of myeloid cells

We here describe a leukemogenic role of the homeobox gene UNCX, activated by epigenetic modifications in acute myeloid leukemia (AML). We found the ectopic activation of UNCX in a leukemia patient harboring a t(7;10)(p22;p14) translocation, in 22 of 61 of additional cases [a total of 23 positive pat...

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Publié dans:Haematologica
Auteurs principaux: Daniele, Giulia, Simonetti, Giorgia, Fusilli, Caterina, Iacobucci, Ilaria, Lonoce, Angelo, Palazzo, Antonio, Lomiento, Mariana, Mammoli, Fabiana, Marsano, Renè Massimiliano, Marasco, Elena, Mantovani, Vilma, Quentmeier, Hilmar, Drexler, Hans G, Ding, Jie, Palumbo, Orazio, Carella, Massimo, Nadarajah, Niroshan, Perricone, Margherita, Ottaviani, Emanuela, Baldazzi, Carmen, Testoni, Nicoletta, Papayannidis, Cristina, Ferrari, Sergio, Mazza, Tommaso, Martinelli, Giovanni, Storlazzi, Clelia Tiziana
Format: Artigo
Langue:Inglês
Publié: Ferrata Storti Foundation 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5566027/
https://ncbi.nlm.nih.gov/pubmed/28411256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2016.163022
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