Residue 21 of human granulocyte-macrophage colony-stimulating factor is critical for biological activity and for high but not low affinity binding.

The functional role of the predicted first alpha-helix of human granulocyte-macrophage colony-stimulating factor (GM-CSF) was analysed by site-directed mutagenesis and multiple biological and receptor binding assays. Initial deletion mutagenesis pointed to residues 20 and 21 being critical. Substitu...

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Hlavní autoři: Lopez, A F, Shannon, M F, Hercus, T, Nicola, N A, Cambareri, B, Dottore, M, Layton, M J, Eglinton, L, Vadas, M A
Médium: Artigo
Jazyk:Inglês
Vydáno: 1992
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC556531/
https://ncbi.nlm.nih.gov/pubmed/1532144
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