Residue 21 of human granulocyte-macrophage colony-stimulating factor is critical for biological activity and for high but not low affinity binding.

The functional role of the predicted first alpha-helix of human granulocyte-macrophage colony-stimulating factor (GM-CSF) was analysed by site-directed mutagenesis and multiple biological and receptor binding assays. Initial deletion mutagenesis pointed to residues 20 and 21 being critical. Substitu...

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Publicado en:EMBO J
Autores principales: Lopez, A F, Shannon, M F, Hercus, T, Nicola, N A, Cambareri, B, Dottore, M, Layton, M J, Eglinton, L, Vadas, M A
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 1992
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC556531/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1532144/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1992.tb05129.x
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