Cloning of the complete biosynthetic gene cluster for an aminonucleoside antibiotic, puromycin, and its regulated expression in heterologous hosts.

Puromycin, produced by Streptomyces alboniger, is a member of the large group of aminonucleoside antibiotics. The genes pac and dmpM, encoding a puromycin N-acetyl transferase and an O-demethyl puromycin O-methyltransferase, respectively, are tightly linked in the DNA of S. alboniger. The entire set...

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Bibliografiske detaljer
Udgivet i:EMBO J
Main Authors: Lacalle, R A, Tercero, J A, Jiménez, A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC556512/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1537349/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1992.tb05112.x
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