Structural homologies between phenformin, lipitor and gleevec aim the same metabolic oncotarget in leukemia and melanoma

Phenformin's recently demonstrated efficacy in melanoma and Gleevec's demonstrated anti-proliferative action in chronic myeloid leukemia may lie within these drugs' significant pharmacokinetics, pharmacodynamics and structural homologies, which are reviewed herein. Gleevec's succ...

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Publicat a:Oncotarget
Autors principals: Somlyai, Gábor, Collins, T. Que, Meuillet, Emmanuelle J., Hitendra, Patel, D'Agostino, Dominic P., Boros, László G.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2017
Matèries:
Review
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564842/
https://ncbi.nlm.nih.gov/pubmed/28418852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16238
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