Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes.

The biosynthesis of MHC Class II molecules starts with the assembly of the alpha and beta subunits and the invariant chain. Intracellular transport of Class II molecules was followed in pulse-chase experiments of a human Epstein-Barr virus-transformed B lymphoblastoid cell line. Entry of Class II mo...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Neefjes, J J, Ploegh, H L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC556469/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1311249/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1992.tb05069.x
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