Estrogen-activated MDM2 disrupts mammary tissue architecture through a p53-independent pathway

The Cancer Genome Atlas (TCGA) data indicate that high MDM2 expression correlates with all subtypes of breast cancer. Overexpression of MDM2 drives breast oncogenesis in the presence of wild-type or mutant p53 (mtp53). Importantly, estrogen-receptor positive (ER+) breast cancers overexpress MDM2 and...

Full description

Saved in:
Bibliographic Details
Published in:Oncotarget
Main Authors: Kundu, Nandini, Brekman, Angelika, Kim, Jun Yeob, Xiao, Gu, Gao, Chong, Bargonetti, Jill
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2017
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564615/
https://ncbi.nlm.nih.gov/pubmed/28615518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18147
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items