Evaluation of radiofluorinated carboximidamides as potential IDO-targeted PET tracers for cancer imaging

IDO1 is an enzyme catalyzing the initial and rate-limiting step in the catabolism of tryptophan along the kynurenine pathway. IDO1 expression could suppress immune responses by blocking T-lymphocyte proliferation locally, suggesting a role of IDO in the regulation of immune responses. The goal of th...

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Vydáno v:Oncotarget
Hlavní autoři: Huang, Xuan, Pan, Zhongjie, Doligalski, Michael L, Xiao, Xia, Ruiz, Epifanio, Budzevich, Mikalai M, Tian, Haibin
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564531/
https://ncbi.nlm.nih.gov/pubmed/28159919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14898
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