Use of a MCL-1 inhibitor alone to de-bulk melanoma and in combination to kill melanoma initiating cells

MCL-1 (BCL-2 family anti-apoptotic protein) is responsible for melanoma's resistance to therapy. Cancer initiating cells also contribute to resistance and relapse from treatments. Here we examined the effects of the MCL-1 inhibitor SC-2001 in killing non melanoma-initiating-cells (bulk of melan...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Mukherjee, Nabanita, Lu, Yan, Almeida, Adam, Lambert, Karoline, Shiau, Chung-Wai, Su, Jung-Chen, Luo, Yuchun, Fujita, Mayumi, Robinson, William A., Robinson, Steven E., Norris, David A., Shellman, Yiqun G.
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564524/
https://ncbi.nlm.nih.gov/pubmed/27086916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8695
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