Darbepoetin administration to neonates undergoing cooling for encephalopathy: a safety and pharmacokinetic trial

BACKGROUND: Despite therapeutic hypothermia, neonates with encephalopathy (NE) have high rates of death or disability. Darbepoetin alfa (Darbe) has comparable biological activity to erythropoietin, but has extended circulating half-life (t(1/2)). Our aim was to determine Darbe safety and pharmacokin...

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Bibliografski detalji
Izdano u:Pediatr Res
Glavni autori: Baserga, Mariana C., Beachy, Joanna C., Roberts, Jessica K., Ward, Robert M., DiGeronimo, Robert J., Walsh, William F., Ohls, Robin K., Anderson, Jennifer, Mayock, Dennis E., Juul, Sandra E., Christensen, Robert D., Loertscher, Manndi C., Stockmann, Chris, Sherwin, Catherine M.T., Spigarelli, Michael G., Yoder, Bradley A.
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564328/
https://ncbi.nlm.nih.gov/pubmed/25996892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2015.101
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