Darbepoetin administration to neonates undergoing cooling for encephalopathy: a safety and pharmacokinetic trial

BACKGROUND: Despite therapeutic hypothermia, neonates with encephalopathy (NE) have high rates of death or disability. Darbepoetin alfa (Darbe) has comparable biological activity to erythropoietin, but has extended circulating half-life (t(1/2)). Our aim was to determine Darbe safety and pharmacokin...

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Detalhes bibliográficos
Publicado no:Pediatr Res
Main Authors: Baserga, Mariana C., Beachy, Joanna C., Roberts, Jessica K., Ward, Robert M., DiGeronimo, Robert J., Walsh, William F., Ohls, Robin K., Anderson, Jennifer, Mayock, Dennis E., Juul, Sandra E., Christensen, Robert D., Loertscher, Manndi C., Stockmann, Chris, Sherwin, Catherine M.T., Spigarelli, Michael G., Yoder, Bradley A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564328/
https://ncbi.nlm.nih.gov/pubmed/25996892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2015.101
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