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Selective neuronal vulnerability in Parkinson disease

Intracellular α-synuclein (α-syn)-rich protein aggregates called Lewy pathology (LP) and neuronal death are commonly found in the brains of patients with clinical Parkinson disease (cPD). It is widely believed that LP appears early in the disease and spreads in synaptically coupled brain networks, d...

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Bibliografske podrobnosti
izdano v:Nat Rev Neurosci
Main Authors: Surmeier, D. James, Obeso, José A., Halliday, Glenda M.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564322/
https://ncbi.nlm.nih.gov/pubmed/28104909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrn.2016.178
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