Evaluation of the Antidepressant Therapeutic Potential of Isocyanine and Pseudoisocyanine Analogues of the Organic Cation Decynium-22

Herein we describe the synthesis and evaluation of antidepressant properties of seven analogues (1–7) of the low affinity/high capacity transporter blocker decynium-22 (D-22). All analogues (1–7) were synthesized via base promoted coupling reactions between N-alkylated-2-methylquinolinium iodides or...

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Pubblicato in:Eur J Med Chem
Autori principali: Krause-Heuer, Anwen M., Fraser-Spears, Rheaclare, Dobrowolski, Jeremy C., Ashford, Mark E., Wyatt, Naomi A., Roberts, Maxine P., Gould, Georgianna G., Cheah, Wai-Ching, Ng, Clarissa K. L., Bhadbhade, Mohan, Zhang, Bo, Greguric, Ivan, Wheate, Nial J., Kumar, Naresh, Koek, Wouter, Callaghan, Paul D., Daws, Lynette C., Fraser, Benjamin H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564211/
https://ncbi.nlm.nih.gov/pubmed/28624702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2017.06.011
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