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Structural basis for the regulatory interactions of proapoptotic Par-4
Par-4 is a unique proapoptotic protein with the ability to induce apoptosis selectively in cancer cells. The X-ray crystal structure of the C-terminal domain of Par-4 (Par-4(CC)), which regulates its apoptotic function, was obtained by MAD phasing. Par-4 homodimerizes by forming a parallel coiled-co...
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| Publicado no: | Cell Death Differ |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5563986/ https://ncbi.nlm.nih.gov/pubmed/28622290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.76 |
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