Structural basis for the regulatory interactions of proapoptotic Par-4

Par-4 is a unique proapoptotic protein with the ability to induce apoptosis selectively in cancer cells. The X-ray crystal structure of the C-terminal domain of Par-4 (Par-4(CC)), which regulates its apoptotic function, was obtained by MAD phasing. Par-4 homodimerizes by forming a parallel coiled-co...

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Publicat a:Cell Death Differ
Autors principals: Tiruttani Subhramanyam, Udaya K, Kubicek, Jan, Eidhoff, Ulf B, Labahn, Joerg
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563986/
https://ncbi.nlm.nih.gov/pubmed/28622290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.76
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