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The Transcription Factor NFAT1 Participates in the Induction of CD4(+) T Cell Functional Exhaustion during Plasmodium yoelii Infection

Repeated stimulation of T cells that occurs in the context of chronic infection results in progressively reduced responsiveness of T cells to pathogen-derived antigens. This phenotype, known as T cell exhaustion, occurs during chronic infections caused by a variety of pathogens, from persistent viru...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Ames, Rachel Y., Ting, Li-Min, Gendlina, Inessa, Kim, Kami, Macian, Fernando
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563568/
https://ncbi.nlm.nih.gov/pubmed/28630062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00364-17
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