Establishment of NF-κB sensing and IL-4 secreting mesenchymal stromal cells as an “on-demand” drug delivery system to modulate inflammation

Chronic inflammation is associated with upregulation of the transcription factor NF-κB and excessive inflammatory cytokine secretion by M1 macrophages. The anti-inflammatory cytokine IL-4 converts pro-inflammatory M1 macrophages into an anti-inflammatory and tissue regenerative M2 phenotype, thus re...

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Detalhes bibliográficos
Publicado no:Cytotherapy
Main Authors: Lin, Tzuhua, Pajarinen, Jukka, Nabeshima, Akira, Lu, Laura, Nathan, Karthik, Yao, Zhenyu, Goodman, Stuart B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563472/
https://ncbi.nlm.nih.gov/pubmed/28739167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcyt.2017.06.008
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