Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer

The proto-oncogene PTTG and its binding partner PBF have been widely studied in multiple cancer types, particularly thyroid and colorectal, but their combined role in tumourigenesis is uncharacterised. Here, we show for the first time that together PTTG and PBF significantly modulate DNA damage resp...

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Udgivet i:Oncogene
Main Authors: Read, Martin L., Fong, Jim C.W., Modasia, Bhavika, Fletcher, Alice, Imruetaicharoenchoke, Waraporn, Thompson, Rebecca, Nieto, Hannah, Reynolds, John J., Bacon, Andrea, Mallick, Ujjal, Hackshaw, Allan, Watkinson, John C., Boelaert, Kristien, Turnell, Andrew S., Smith, Vicki E., McCabe, Christopher J.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563453/
https://ncbi.nlm.nih.gov/pubmed/28504713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.154
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