Elucidation of Molecular Mechanisms of Streptozotocin-Induced Oxidative Stress, Apoptosis, and Mitochondrial Dysfunction in Rin-5F Pancreatic β-Cells

Streptozotocin is a pancreatic beta-cell-specific cytotoxin and is widely used to induce experimental type 1 diabetes in rodent models. The precise molecular mechanism of STZ cytotoxicity is however not clear. Studies have suggested that STZ is preferably absorbed by insulin-secreting β-cells and in...

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Bibliografiska uppgifter
I publikationen:Oxid Med Cell Longev
Huvudupphovsmän: Nahdi, Arwa M. T. Al, John, Annie, Raza, Haider
Materialtyp: Artigo
Språk:Inglês
Publicerad: Hindawi 2017
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563420/
https://ncbi.nlm.nih.gov/pubmed/28845214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/7054272
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