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Molecular Determinants for STIM1 Activation During Store Operated Ca(2+) Entry

BACKGROUND: STIM/ORAI-mediated store-operated Ca(2+) entry (SOCE) mediates a myriad of Ca(2+)-dependent cellular activities in mammals. Genetic defects in STIM1/ORAI1 lead to devastating severe combined immunodeficiency; whereas gain-of-function mutations in STIM1/ORAI1 are intimately associated wit...

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Udgivet i:Curr Mol Med
Main Authors: Ma, G., Zheng, S., Ke, Y., Zhou, L., He, L., Huang, Y., Wang, Y., Zhou, Y.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563273/
https://ncbi.nlm.nih.gov/pubmed/28231751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1566524017666170220103731
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