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The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy

Neuropathic pain remains a prevalent and persistent clinical problem because of our incomplete understanding of its pathogenesis. This study demonstrates for the first time, to our knowledge, a critical role for CNS innate immunity by means of microglial Toll-like receptor 4 (TLR4) in the induction...

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Detalhes bibliográficos
Main Authors: Tanga, Flobert Y., Nutile-McMenemy, Nancy, DeLeo, Joyce A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC556308/
https://ncbi.nlm.nih.gov/pubmed/15809417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501634102
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