RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model

Huntington's disease (HD) is a fatal, dominant neurogenetic disorder. HD results from polyglutamine repeat expansion (CAG codon, Q) in exon 1 of HD, conferring a toxic gain of function on the protein huntingtin (htt). Currently, no preventative treatment exists for HD. RNA interference (RNAi) h...

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Detalhes bibliográficos
Main Authors: Harper, Scott Q., Staber, Patrick D., He, Xiaohua, Eliason, Steven L., Martins, Inês H., Mao, Qinwen, Yang, Linda, Kotin, Robert M., Paulson, Henry L., Davidson, Beverly L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC556303/
https://ncbi.nlm.nih.gov/pubmed/15811941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501507102
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