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Late-onset motoneuron disease caused by a functionally modified AMPA receptor subunit

Amyotrophic lateral sclerosis (ALS) is a devastating disorder of the central nervous system in middle and old age that leads to progressive loss of spinal motoneurons. Transgenic mice overexpressing mutated human Cu(2+)/Zn(2+) superoxide dismutase 1 (SOD1) reproduce clinical features of the familial...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kuner, Rohini, Groom, Anthony J., Bresink, Iris, Kornau, Hans-Christian, Stefovska, Vanya, Müller, Gerald, Hartmann, Bettina, Tschauner, Karsten, Waibel, Stefan, Ludolph, Albert C., Ikonomidou, Chrysanthy, Seeburg, Peter H., Turski, Lechoslaw
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2005
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC556301/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15827116/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0501316102
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