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Age exacerbates microglial activation, oxidative stress, inflammatory and NOX2 gene expression, and delays functional recovery in a middle-aged rodent model of spinal cord injury

BACKGROUND: Spinal cord injury (SCI) among people over age 40 has been steadily increasing since the 1980s and is associated with worsened outcome than injuries in young people. Age-related increases in reactive oxygen species (ROS) are suggested to lead to chronic inflammation. The NADPH oxidase 2...

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Bibliografiske detaljer
Udgivet i:J Neuroinflammation
Main Authors: von Leden, Ramona E., Khayrullina, Guzal, Moritz, Kasey E., Byrnes, Kimberly R.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563003/
https://ncbi.nlm.nih.gov/pubmed/28821269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0933-3
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