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The nucleotide switch in Cdc42 modulates coupling between the GTPase-binding and allosteric equilibria of Wiskott–Aldrich syndrome protein

The GTP/GDP nucleotide switch in Ras superfamily GTPases generally involves differential affinity toward downstream effectors, with the GTP-bound state having a higher affinity for effector than the GDP-bound state. We have developed a quantitative model of allosteric regulation of the Wiskott–Aldri...

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Autors principals: Leung, Daisy W., Rosen, Michael K.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC556282/
https://ncbi.nlm.nih.gov/pubmed/15821030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406472102
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