Voltage-dependent blockade by bupivacaine of cardiac sodium channels expressed in Xenopus oocytes

Bupivacaine ranks as the most potent and efficient drug among class I local anesthetics, but its high potential for toxic reactions severely limits its clinical use. Although bupivacaine-induced toxicity is mainly caused by substantial blockade of voltage-gated sodium channels (VGSCs), how these hyd...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neurosci Bull
Prif Awduron: Zhang, Heng, Ji, Hui, Liu, Zhirui, Ji, Yonghua, You, Xinmin, Ding, Gang, Cheng, Zhijun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2014
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562622/
https://ncbi.nlm.nih.gov/pubmed/25008571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12264-013-1449-1
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