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Voltage-dependent blockade by bupivacaine of cardiac sodium channels expressed in Xenopus oocytes
Bupivacaine ranks as the most potent and efficient drug among class I local anesthetics, but its high potential for toxic reactions severely limits its clinical use. Although bupivacaine-induced toxicity is mainly caused by substantial blockade of voltage-gated sodium channels (VGSCs), how these hyd...
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| Udgivet i: | Neurosci Bull |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5562622/ https://ncbi.nlm.nih.gov/pubmed/25008571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12264-013-1449-1 |
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