Voltage-dependent blockade by bupivacaine of cardiac sodium channels expressed in Xenopus oocytes

Bupivacaine ranks as the most potent and efficient drug among class I local anesthetics, but its high potential for toxic reactions severely limits its clinical use. Although bupivacaine-induced toxicity is mainly caused by substantial blockade of voltage-gated sodium channels (VGSCs), how these hyd...

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Bibliografiske detaljer
Udgivet i:Neurosci Bull
Main Authors: Zhang, Heng, Ji, Hui, Liu, Zhirui, Ji, Yonghua, You, Xinmin, Ding, Gang, Cheng, Zhijun
Format: Artigo
Sprog:Inglês
Udgivet: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2014
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562622/
https://ncbi.nlm.nih.gov/pubmed/25008571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12264-013-1449-1
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