Targeting Mycobacterium tuberculosis sensitivity to thiol stress at acidic pH kills the bacterium and potentiates antibiotics

Mycobacterium tuberculosis (Mtb) must sense and adapt to immune pressures such as acidic pH during pathogenesis. The goal of this study was to isolate compounds that inhibit acidic pH resistance, thus defining virulence pathways that are vulnerable to chemotherapy. Here we report that the compound A...

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Veröffentlicht in:Cell Chem Biol
Hauptverfasser: Coulson, Garry B., Johnson, Benjamin K., Zheng, Huiqing, Colvin, Christopher J., Fillinger, Robert J., Haiderer, Elizabeth R., Hammer, Neal D., Abramovitch, Robert B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562523/
https://ncbi.nlm.nih.gov/pubmed/28781126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.06.018
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