Blockade of the LRP16-PKR-NF-κB signaling axis sensitizes colorectal carcinoma cells to DNA-damaging cytotoxic therapy

Acquired therapeutic resistance by tumors is a substantial impediment to reducing the morbidity and mortality that are attributable to human malignancies. The mechanisms responsible for the dramatic shift between chemosensitivity and chemoresistance in colorectal carcinoma have not been defined. Her...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Li, Xiaolei, Wu, Zhiqiang, An, Xiaojing, Mei, Qian, Bai, Miaomiao, Hanski, Leena, Li, Xiang, Ahola, Tero, Han, Weidong
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562444/
https://ncbi.nlm.nih.gov/pubmed/28820388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27301
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