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Conflicting Interpretation of Genetic Variants and Cancer Risk by Commercial Laboratories as Assessed by the Prospective Registry of Multiplex Testing

PURPOSE: Massively parallel sequencing allows simultaneous testing of multiple genes associated with cancer susceptibility. Guidelines are available for variant classification; however, interpretation of these guidelines by laboratories and providers may differ and lead to conflicting reporting and,...

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Détails bibliographiques
Publié dans:J Clin Oncol
Auteurs principaux: Balmaña, Judith, Digiovanni, Laura, Gaddam, Pragna, Walsh, Michael F., Joseph, Vijai, Stadler, Zsofia K., Nathanson, Katherine L., Garber, Judy E., Couch, Fergus J., Offit, Kenneth, Robson, Mark E., Domchek, Susan M.
Format: Artigo
Langue:Inglês
Publié: American Society of Clinical Oncology 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562435/
https://ncbi.nlm.nih.gov/pubmed/27621404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2016.68.4316
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