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Single-cell RNA Sequencing Reveals an Altered Gene Expression Pattern as a Result of CRISPR/cas9-mediated Deletion of Gene 33/Mig6 and Chronic Exposure to Hexavalent Chromium in Human Lung Epithelial Cells

Gene 33 (Mig6, ERRFI1) is an adaptor protein with multiple cellular functions. We recently reported that depletion of this protein promotes lung epithelial cell transformation induced by hexavalent chromium [Cr(VI)]. However, the early molecular events that mediate this process are not clear. In the...

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Detalhes bibliográficos
Publicado no:Toxicol Appl Pharmacol
Main Authors: Park, Soyoung, Zhang, Xiaowen, Li, Cen, Yin, Changhong, Li, Jiangwei, Fallon, John T., Huang, Weihua, Xu, Dazhong
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562372/
https://ncbi.nlm.nih.gov/pubmed/28688920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2017.07.003
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