Nuclear Gene 33/Mig6 regulates the DNA damage response through an ATM serine/threonine kinase–dependent mechanism

Gene 33 (Mig6, ERRFI1) is an adaptor protein with multiple cellular functions. We recently linked Gene 33 to the DNA damage response (DDR) induced by hexavalent chromium (Cr(VI)), but the molecular mechanism remains unknown. Here we show that ectopic expression of Gene 33 triggers DDR in an ATM seri...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Li, Cen, Park, Soyoung, Zhang, Xiaowen, Eisenberg, Leonard M., Zhao, Hong, Darzynkiewicz, Zbigniew, Xu, Dazhong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5633135/
https://ncbi.nlm.nih.gov/pubmed/28842482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.803338
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