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Phosphatidlyinositol-3-kinase C2 beta (PI3KC2β) is a potential new target to treat IgE mediated disease

Cross linking of the IgE receptor (FcεRI) on mast cells plays a critical role in IgE-dependent allergy including allergic rhinitis, asthma, anaphylaxis, and delayed type hypersensitivity reactions. The Ca(2+) activated K(+) channel, KCa3.1, plays a critical role in IgE-stimulated Ca(2+) entry and de...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Srivastava, Shekhar, Li, Zhai, Skolnik, Edward Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562315/
https://ncbi.nlm.nih.gov/pubmed/28820911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0183474
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