Inhibition of eukaryotic translation by the antitumor natural product Agelastatin A

Protein synthesis plays an essential role in cell proliferation, differentiation and survival. Inhibitors of eukaryotic translation have entered the clinic, establishing the translation machinery as a promising target for chemotherapy. A recently discovered, structurally unique marine sponge-derived...

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Veröffentlicht in:Cell Chem Biol
Hauptverfasser: McClary, Brandon, Zinshteyn, Boris, Meyer, Melanie, Jouanneau, Morgan, Pellegrino, Simone, Yusupova, Gulnara, Schuller, Anthony, Reyes, Jeremy Chris P., Lu, Junyan, Guo, Zufeng, Ayinde, Safiat, Luo, Cheng, Dang, Yongjun, Romo, Daniel, Yusupov, Marat, Green, Rachel, Liu, Jun O.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562292/
https://ncbi.nlm.nih.gov/pubmed/28457705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.04.006
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