Type 2 diabetes variants disrupt function of SLC16A11 through two distinct mechanisms

Type 2 Diabetes (T2D) affects Latinos at twice the rate seen in populations of European descent. We recently identified a risk haplotype spanning SLC16A11 that explains ~20% of the increased T2D prevalence in Mexico. Here, through genetic fine-mapping, we define a set of tightly-linked variants like...

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Veröffentlicht in:Cell
Hauptverfasser: Rusu, Victor, Hoch, Eitan, Mercader, Josep M., Tenen, Danielle E., Gymrek, Melissa, Hartigan, Christina R., DeRan, Michael, von Grotthuss, Marcin, Fontanillas, Pierre, Spooner, Alexandra, Guzman, Gaelen, Deik, Amy A., Pierce, Kerry A., Dennis, Courtney, Clish, Clary B., Carr, Steven A., Wagner, Bridget K., Schenone, Monica, Ng, Maggie C.Y., Chen, Brian H., Centeno-Cruz, Federico, Zerrweck, Carlos, Orozco, Lorena, Altshuler, David M., Schreiber, Stuart L., Florez, Jose C., Jacobs, Suzanne B. R., Lander, Eric S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562285/
https://ncbi.nlm.nih.gov/pubmed/28666119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.06.011
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