Race, Gender, and Genetic Polymorphism Contribute to Variability in Acetaminophen Pharmacokinetics, Metabolism, and Protein-Adduct Concentrations in Healthy African-American and European-American Volunteers

Over 30 years ago, black Africans from Kenya and Ghana were shown to metabolize acetaminophen faster by glucuronidation and slower by oxidation compared with white Scottish Europeans. The objectives of this study were to determine whether similar differences exist between African-Americans and Europ...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Court, Michael H., Zhu, Zhaohui, Masse, Gina, Duan, Su X., James, Laura P., Harmatz, Jerold S., Greenblatt, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2017
Assuntos:
Metabolism, Transport, and Pharmacogenomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562097/
https://ncbi.nlm.nih.gov/pubmed/28663312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.242107
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