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Osteopontin deficiency protects mice from cholesterol gallstone formation by reducing expression of intestinal NPC1L1

Homeostasis of cholesterol is regulated by absorption in the intestine and synthesis in the liver. The authors previously demonstrated that OPN (osteopontin) exhibits the ability to alter hepatic cholesterol metabolism, thus affecting cholesterol gallstone formation in mice. The present study invest...

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Detalhes bibliográficos
Publicado no:Mol Med Rep
Main Authors: Lin, Jing, Shao, Wei-Qing, Chen, Qing-Zhi, Zhu, Wen-Wei, Lu, Lu, Jia, Hu-Liang, Chen, Jin-Hong
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5561929/
https://ncbi.nlm.nih.gov/pubmed/28627641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2017.6774
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