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Osteopontin deficiency protects mice from cholesterol gallstone formation by reducing expression of intestinal NPC1L1

Homeostasis of cholesterol is regulated by absorption in the intestine and synthesis in the liver. The authors previously demonstrated that OPN (osteopontin) exhibits the ability to alter hepatic cholesterol metabolism, thus affecting cholesterol gallstone formation in mice. The present study invest...

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Dades bibliogràfiques
Publicat a:Mol Med Rep
Autors principals: Lin, Jing, Shao, Wei-Qing, Chen, Qing-Zhi, Zhu, Wen-Wei, Lu, Lu, Jia, Hu-Liang, Chen, Jin-Hong
Format: Artigo
Idioma:Inglês
Publicat: D.A. Spandidos 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5561929/
https://ncbi.nlm.nih.gov/pubmed/28627641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2017.6774
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