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Dysfunction of two lysosome degradation pathways of α-synuclein in Parkinson’s disease: potential therapeutic targets?
Parkinson’s disease (PD) is pathologically characterized by the presence of α-synuclein (α-syn)-positive intracytoplasmic inclusions named Lewy bodies in the dopaminergic neurons of the substantia nigra. A series of morbid consequences are caused by pathologically high amounts or mutant forms of α-s...
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| Publicado en: | Neurosci Bull |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5561915/ https://ncbi.nlm.nih.gov/pubmed/22961477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12264-012-1263-1 |
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