Histone deacetylase-2 is involved in stress-induced cognitive impairment via histone deacetylation and PI3K/AKT signaling pathway modification

Exposure to chronic stress upregulates blood glucocorticoid levels and impairs cognition via diverse epigenetic mechanisms, such as histone deacetylation. Histone deacetylation can lead to transcriptional silencing of many proteins involved in cognition and may also cause learning and memory dysfunc...

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Detalhes bibliográficos
Publicado no:Mol Med Rep
Main Authors: Wu, Jie, Liu, Cui, Zhang, Ling, Qu, Chun-Hui, Sui, Xiao-Long, Zhu, Hua, Huang, Lan, Xu, Yan-Feng, Han, Yun-Lin, Qin, Chuan
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5561802/
https://ncbi.nlm.nih.gov/pubmed/28656275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2017.6840
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