Shared peptide binding of HLA Class I and II alleles associate with cutaneous nevirapine hypersensitivity and identify novel risk alleles

Genes of the human leukocyte antigen (HLA) system encode cell-surface proteins involved in regulation of immune responses, and the way drugs interact with the HLA peptide binding groove is important in the immunopathogenesis of T-cell mediated drug hypersensitivity syndromes. Nevirapine (NVP), is an...

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Publicado no:Sci Rep
Main Authors: Pavlos, Rebecca, McKinnon, Elizabeth J., Ostrov, David A., Peters, Bjoern, Buus, Soren, Koelle, David, Chopra, Abha, Schutte, Ryan, Rive, Craig, Redwood, Alec, Restrepo, Susana, Bracey, Austin, Kaever, Thomas, Myers, Paisley, Speers, Ellen, Malaker, Stacy A., Shabanowitz, Jeffrey, Jing, Yuan, Gaudieri, Silvana, Hunt, Donald F., Carrington, Mary, Haas, David W., Mallal, Simon, Phillips, Elizabeth J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5561238/
https://ncbi.nlm.nih.gov/pubmed/28819312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08876-0
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